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The mission of the Cancer Health Equity, Education and Research (CHEER) Lab is to reduce the burden of cancer on vulnerable and underserved populations. To work toward this mission, the CHEER Lab is focused on building scientific evidence of the individual, interpersonal and organizational factors that influence cancer-related risks (e.g., tobacco use), preventive behaviors (e.g., HPV vaccination and cancer screening) and healthcare delivery (e.g., cancer survivorship care). We apply mixed methods approaches including survey research, experimental designs, in-depth qualitative methods and social media analytics. This research evidence is then used to develop culturally responsive interventions to improve equity in cancer prevention and cancer care delivery.