Despite multifaceted pharmacotherapeutic options available, the global burden of controlled and uncontrolled cardiovascular disease and metabolic syndrome has been ceaselessly rising over the past decades, highlighting the unmet needs for prevention efforts to curve this public health epidemic. Notably, physical inactivity has been recognized as the most prevalent modifiable risk factor for development of diseases associated with aging. To this end, understanding the fundamental molecular mechanisms of exercise is crucial as it can provide insights into the pathological processes during disease development and may lead to the discovery of novel molecular therapeutic targets. Using cutting-edge biotechnologies, the Translational Exercise Biology Laboratory (TEBL) focuses on answering questions such as:

  • What are the physiological changes following physical activity at the organ and tissue level?
  • How does the body adapt to a stimulus at the cellular level when it persists repeatedly and chronically?
  • Are changes in serological biomarkers following cerebrovascular brain injury in response to sports-related mild traumatic brain injury?

The innovative approaches the laboratory is taking include nanotechnology, bioinformatics, molecular physiology and genomics. Furthermore, the transformative research models being used include, but are not limited to, “organ-on-a-chip” model, primary human tissue culture, liquid biopsy, transgenic mouse models, site-directed mutagenesis, random DNA mutation capturing, extracellular vesicle-based high-throughput biomarker screening, next generation sequencing, and metabolomic profiling other -omics technologies.

Learn more about TEBL.

Director

Joon-Young Park headshot

Joon-Young Park

Associate Professor
Kinesiology
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Phone
215-204-1957
Office

Pearson Hall 265
1800 N. Broad Street
Philadelphia, PA 19122