Joon Young Park

Associate Professor
Kinesiology
Office
1800 N. Broad Street

Biography

Joon-Young Park is an associate professor of kinesiology in the College of Public Health at Temple University. He is a professional member of American Physiological Society, American Heart Association and American College of Sports Medicine. He previously has served or currently serves as an editorial board member for several scientific journals including Exercise and Sport Science Reviews, Clinical Science, Integrative Medicine Research, and Journal of Exercise Rehabilitation. He is a recipient of the Scientist Development Grant Award and Certificate of Research Excellence Award from the American Heart Association. He is the author or co-author of more than 30 peer-reviewed articles, over 60 refereed conference proceedings and four book chapters.

Dr. Park's current research focuses on determining the molecular basis of exercise effects on vascular disease and function. Exercise is the most potent nonpharmacological interventions for cardiovascular diseases. Understanding the fundamental molecular mechanisms of the exercise effects is crucial as it can provide insights into the pathological processes during disease development and may lead to the discovery of novel therapeutic targets. Current research projects focus on answering such questions as: How can the physiological changes during exercise be defined at the cellular level? How do endothelial cells respond to those associated stimuli? What mediates cellular responses to the stimulus? And, how do cells adapt to the stimulus when it persists repeatedly and chronically? His teaching includes courses in the context of integrative exercise physiology in cardiovascular, neuromuscular and metabolic systems.

Curriculum Vitae 

Courses Taught

Number

Name

Level

KINS 9201

Cardiovascular Exercise Physiology

Graduate

KINS 9203

Appl Ex Physio-Neuromusc

Graduate

KINS 9204

Cellular Adapt to Exer

Graduate

HRPR 5999

Research Experience in Health Professions

Graduate

Selected Publications

  • Kim, J.S., Sayoc, J., Baek, K.W., & Park, J.Y. (2021). Laminar shear stress protects against premature endothelial senescence by sirt1-dependent mechanisms. Exercise Science, 30(2), pp. 213-220. doi: 10.15857/KSEP.2021.30.2.213

  • Hong, J., Hong, S., Lee, J., Park, J., Eriksen, J.L., Rooney, B.V., & Park, Y. (2020). Exercise training ameliorates cerebrovascular dysfunction in a murine model of Alzheimer's disease: role of the P2Y2 receptor and endoplasmic reticulum stress. Am J Physiol Heart Circ Physiol, 318(6), pp. H1559-H1569. United States. doi: 10.1152/ajpheart.00129.2020

  • Kim, T., Park, S., Park, J., & Park, H. (2020). Infusion of Plasma from Exercised Mice Ameliorates Cognitive Dysfunction by Increasing Hippocampal Neuroplasticity and Mitochondrial Functions in 3xTg-AD Mice. Int J Mol Sci, 21(9). Switzerland. doi: 10.3390/ijms21093291

  • Tian, R., Colucci, W.S., Arany, Z., Bachschmid, M.M., Ballinger, S.W., Boudina, S., Bruce, J.E., Busija, D.W., Dikalov, S., Dorn, G.W., Galis, Z.S., Gottlieb, R.A., Kelly, D.P., Kitsis, R.N., Kohr, M.J., Levy, D., Lewandowski, E.D., McClung, J.M., Mochly-Rosen, D., O'Brien, K.D., O'Rourke, B., Park, J., Ping, P., Sack, M.N., Sheu, S., Shi, Y., Shiva, S., Wallace, D.C., Weiss, R.G., Vernon, H.J., Wong, R., & Longacre, L.S. (2019). Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop. Circulation, 140(14), pp. 1205-1216. United States. doi: 10.1161/CIRCULATIONAHA.119.040551

  • Joo, H., Park, J., & Rhyu, H. (2019). Effects of the senior welfare center exercise program on body shape, physical fitness level, and cardiovascular health-related factors in old man from Korean rural areas. J Exerc Rehabil, 15(2), pp. 282-286. Korea (South). doi: 10.12965/jer.1938072.036

  • Kim, J. & Park, J. (2019). Effects of resveratrol on laminar shear stress-induced mitochondrial biogenesis in human vascular endothelial cells. J Exerc Nutrition Biochem, 23(1), pp. 7-12. Korea (South). doi: 10.20463/jenb.2019.0002

  • Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I.D., Maning, J., Lucchese, A.M., Shanmughapriya, S., Tomar, D., Park, J.Y., Wang, H., Yang, X., Madesh, M., Lymperopoulos, A., Koch, W.J., Christofidou-Solomidou, M., & Drosatos, K. (2019). Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. J Mol Cell Cardiol, 127, pp. 232-245. England. doi: 10.1016/j.yjmcc.2018.12.016

  • Salamah, A., Shin, J., & Park, J. (2019). Effect of NSAIDs on Muscle Adaptations to Resistance Training: A Brief Review. Journal of Public Health Issues and Practices, 3(1). doi: 10.33790/jphip1100132

  • Lee, H., Kim, K., Kim, B., Shin, J., Rajan, S., Wu, J., Chen, X., Brown, M.D., Lee, S., & Park, J. (2018). A cellular mechanism of muscle memory facilitates mitochondrial remodelling following resistance training. J Physiol, 596(18), pp. 4413-4426. England. doi: 10.1113/JP275308

  • Cheng, Z., Shen, X., Jiang, X., Shan, H., Cimini, M., Fang, P.u., Ji, Y., Park, J.Y., Drosatos, K., Yang, X., Kevil, C.G., Kishore, R., & Wang, H. (2018). Hyperhomocysteinemia potentiates diabetes-impaired EDHF-induced vascular relaxation: Role of insufficient hydrogen sulfide. Redox Biol, 16, pp. 215-225. Netherlands. doi: 10.1016/j.redox.2018.02.006

  • Shao, Y., Nanayakkara, G., Cheng, J., Cueto, R., Yang, W.Y., Park, J., Wang, H., & Yang, X. (2018). Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury. Antioxid Redox Signal, 28(10), pp. 973-986. United States. doi: 10.1089/ars.2017.7069

  • Seki, M., Powers, J.C., Maruyama, S., Zuriaga, M.A., Wu, C., Kurishima, C., Kim, L., Johnson, J., Poidomani, A., Wang, T., Muñoz, E., Rajan, S., Park, J.Y., Walsh, K., & Recchia, F.A. (2018). Acute and Chronic Increases of Circulating FSTL1 Normalize Energy Substrate Metabolism in Pacing-Induced Heart Failure. Circ Heart Fail, 11(1), p. e004486. United States. doi: 10.1161/CIRCHEARTFAILURE.117.004486

  • Zeng, H., Nanayakkara, G.K., Shao, Y., Fu, H., Sun, Y.u., Cueto, R., Yang, W.Y., Yang, Q., Sheng, H., Wu, N.a., Wang, L., Yang, W., Chen, H., Shao, L., Sun, J., Qin, X., Park, J.Y., Drosatos, K., Choi, E.T., Zhu, Q., Wang, H., & Yang, X. (2018). DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. Front Physiol, 9, p. 516. Switzerland. doi: 10.3389/fphys.2018.00516

  • Babbitt, D.M., Kim, J., Forrester, S.J., Brown, M.D., & Park, J. (2015). Effect of Interleukin-10 and Laminar Shear Stress on Endothelial Nitric Oxide Synthase and Nitric Oxide in African American Human Umbilical Vein Endothelial Cells. Ethn Dis, 25(4), pp. 413-418. United States. doi: 10.18865/ed.25.4.413

  • Kim, J., Kim, B., Lee, H., Thakkar, S., Babbitt, D.M., Eguchi, S., Brown, M.D., & Park, J. (2015). Shear stress-induced mitochondrial biogenesis decreases the release of microparticles from endothelial cells. Am J Physiol Heart Circ Physiol, 309(3), pp. H425-H433. United States. doi: 10.1152/ajpheart.00438.2014

  • Takayanagi, T., Kawai, T., Forrester, S.J., Obama, T., Tsuji, T., Fukuda, Y., Elliott, K.J., Tilley, D.G., Davisson, R.L., Park, J., & Eguchi, S. (2015). Role of epidermal growth factor receptor and endoplasmic reticulum stress in vascular remodeling induced by angiotensin II. Hypertension, 65(6), pp. 1349-1355. United States. doi: 10.1161/HYPERTENSIONAHA.115.05344

  • Forrester, S.J., Kawata, K., Lee, H., Kim, J., Sebzda, K., Butler, T., Yingling, V.R., & Park, J. (2014). Bioinformatic identification of connective tissue growth factor as an osteogenic protein within skeletal muscle. Physiol Rep, 2(12). United States. doi: 10.14814/phy2.12255

  • Kim, B., Lee, H., Kawata, K., & Park, J. (2014). Exercise-mediated wall shear stress increases mitochondrial biogenesis in vascular endothelium. PLoS One, 9(11), p. e111409. United States. doi: 10.1371/journal.pone.0111409

  • Kim, B., Kim, J., Yoon, Y., Santiago, M.C., Brown, M.D., & Park, J. (2013). Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation. Am J Physiol Regul Integr Comp Physiol, 305(8), pp. R927-R938. United States. doi: 10.1152/ajpregu.00502.2012

  • Wang, P., Ma, W., Park, J., Celi, F.S., Arena, R., Choi, J.W., Ali, Q.A., Tripodi, D.J., Zhuang, J., Lago, C.U., Strong, L.C., Talagala, S.L., Balaban, R.S., Kang, J., & Hwang, P.M. (2013). Increased oxidative metabolism in the Li-Fraumeni syndrome. N Engl J Med, 368(11), pp. 1027-1032. United States. doi: 10.1056/NEJMoa1214091

  • Feairheller, D.L., Park, J., Sturgeon, K.M., Williamson, S.T., Diaz, K.M., Veerabhadrappa, P., & Brown, M.D. (2011). Racial differences in oxidative stress and inflammation: in vitro and in vivo. Clin Transl Sci, 4(1), pp. 32-37. United States. doi: 10.1111/j.1752-8062.2011.00264.x

  • Feairheller, D.L., Park, J., Rizzo, V., Kim, B., & Brown, M.D. (2011). Racial differences in the responses to shear stress in human umbilical vein endothelial cells. Vasc Health Risk Manag, 7, pp. 425-431. New Zealand. doi: 10.2147/VHRM.S22435

  • Brown, M.D., Feairheller, D.L., Thakkar, S., Veerabhadrappa, P., & Park, J. (2011). Racial differences in tumor necrosis factor-α-induced endothelial microparticles and interleukin-6 production. Vasc Health Risk Manag, 7, pp. 541-550. New Zealand. doi: 10.2147/VHRM.S22930

  • Zago, A.S., Park, J.Y., Fenty-Stewart, N., Kokubun, E., & Brown, M.D. (2010). Erratum: Effects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older people (European Journal of Applied Physiology DOI: 10.1007/s00421-010-1568-6). European Journal of Applied Physiology, 110(4), p. 833. doi: 10.1007/s00421-010-1618-0

  • Hanson, E.D., Ludlow, A.T., Sheaff, A.K., Park, J., & Roth, S.M. (2010). ACTN3 genotype does not influence muscle power. Int J Sports Med, 31(11), pp. 834-838. Germany. doi: 10.1055/s-0030-1263116

  • Zago, A.S., Kokubun, E., Fenty-Stewart, N., Park, J., Attipoe, S., Hagberg, J., & Brown, M. (2010). [Effect of physical activity and t-786C polymorphism in blood pressure and blood flow in the elderly]. Arq Bras Cardiol, 95(4), pp. 510-516. Brazil. doi: 10.1590/s0066-782x2010005000126

  • Brinkley, T.E., Fenty-Stewart, N.M., Park, J., Brown, M.D., & Hagberg, J.M. (2009). Plasma nitrate/nitrite levels are unchanged after long-term aerobic exercise training in older adults. Nitric Oxide, 21(3-4), pp. 234-238. United States. doi: 10.1016/j.niox.2009.10.001

  • Park, J., Wang, P., Matsumoto, T., Sung, H.o.J., Ma, W., Choi, J.W., Anderson, S.A., Leary, S.C., Balaban, R.S., Kang, J., & Hwang, P.M. (2009). p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content. Circ Res, 105(7), pp. 705-712. United States. doi: 10.1161/CIRCRESAHA.109.205310

  • Feairheller, D.L., Brown, M.D., Park, J., Brinkley, T.E., Basu, S., Hagberg, J.M., Ferrell, R.E., & Fenty-Stewart, N.M. (2009). Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension. Med Sci Sports Exerc, 41(7), pp. 1421-1428. United States. doi: 10.1249/MSS.0b013e318199cee8

  • Fenty-Stewart, N., Park, J., Roth, S.M., Hagberg, J.M., Basu, S., Ferrell, R.E., & Brown, M.D. (2009). Independent and combined influence of AGTR1 variants and aerobic exercise on oxidative stress in hypertensives. Blood Press, 18(4), pp. 204-212. England. doi: 10.1080/08037050903118706

  • Attipoe, S., Park, J., Fenty, N., Phares, D., & Brown, M. (2008). Oxidative stress levels are reduced in postmenopausal women with exercise training regardless of hormone replacement therapy status. J Women Aging, 20(1-2), pp. 31-45. England. doi: 10.1300/j074v20n01_04

  • Park, J., Farrance, I.K.G., Fenty, N.M., Hagberg, J.M., Roth, S.M., Mosser, D.M., Wang, M.Q.i., Jo, H., Okazaki, T., Brant, S.R., & Brown, M.D. (2007). NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensives. Am J Physiol Heart Circ Physiol, 293(4), pp. H2320-H2327. United States. doi: 10.1152/ajpheart.00186.2007

  • Jones, J.M., Dowling, T.C., Park, J., Phares, D.A., Park, J., Obisesan, T.O., & Brown, M.D. (2007). Differential aerobic exercise-induced changes in plasma aldosterone between African Americans and Caucasians. Exp Physiol, 92(5), pp. 871-879. England. doi: 10.1113/expphysiol.2007.037408

  • Ma, W., Sung, H.o.J., Park, J.Y., Matoba, S., & Hwang, P.M. (2007). A pivotal role for p53: balancing aerobic respiration and glycolysis. J Bioenerg Biomembr, 39(3), pp. 243-246. United States. doi: 10.1007/s10863-007-9083-0

  • Jones, J., Park, J., Dowling, T., Phares, D., Park, J., & Brown, M. (2006). Role of potassium excretion and percent body fat on ethnic differences in plasma aldosterone levels. Ethn Dis, 16(3 Suppl 4), pp. S4-10-4. United States. Retrieved from https://www.ncbi.nlm.nih.gov/

  • Park, J., Ferrell, R.E., Park, J., Hagberg, J.M., Phares, D.A., Jones, J.M., & Brown, M.D. (2005). NADPH oxidase p22phox gene variants are associated with systemic oxidative stress biomarker responses to exercise training. J Appl Physiol (1985), 99(5), pp. 1905-1911. United States. doi: 10.1152/japplphysiol.00380.2005

  • Weiss, E.P., Park, J., McKenzie, J.A., Park, J., Kulaputana, O., Brown, M.D., Phares, D.A., & Hagberg, J.M. (2004). Plasma nitrate/nitrite response to an oral glucose load and the effect of endurance training. Metabolism, 53(5), pp. 673-679. United States. doi: 10.1016/j.metabol.2003.12.017

  • Jin, Y.S., Kim, Y.K., Park, J.Y., & Kim, J.H. (1998). THE CORRELATION BETWEEN THROWING SPEED AND SHOULDER ROTATORS & TRUNK FLEX/EXT IN THE PROFESSIONAL BASEBALL PITCHERS. Medicine & Science in Sports & Exercise, 30(5), p. 31. doi: 10.1097/00005768-199805001-00178