Temple University

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Joon Young Park

Joon Young Park Ph.D. Temple University Department of Kinesiology

Associate Professor
Director, Cardiovascular Genomics Laboratory


265 Pearson Hall (048-01)
Philadelphia, PA 19122
Office: 215-204-1957
Fax: 215-204-4144


  • Seoul National University, B.S.
  • Seoul National University, M.S.
  • University of Maryland, College Park, Ph.D.
  • University of Maryland, American Heart Association Predoctoral Fellow
  • National Heart, Lung and Blood Institution, NIH Postdoctoral Fellow

Course Involvement

Applied Neuromuscular Physiology, KNIS 9203
Cellular Adaptation to Exercise, KNIS 9204
Exercise and Nutrient Metabolism, KNIS 4312/5312
Mentored Research I, KNIS 9683
Independent Research, KNIS 9882


Kim B, Kim JS, Yoon YS, Santiago M, Brown MD, Park JY, Inhibition of Drp1-dependent division impairs myogenic differentiation, American Journal of Physiology – Regul Integr Comp Physiol, (2013) (In press)

Wang PY, Ma W, Park JY, Celi FS, Arena R, Choi JW, Ali QA, Tripodi DJ, Zhuang J, Lago CU, Strong LC, Talagala SL, Balaban RS, Kang JG, Hwang PM, Increase in Oxidative Metabolism in Li-Fraumeni Syndrome, New England Journal of Medicine, (2013) Mar 14;368(11):1027-32.

Feairheller D.L., Park J.Y., Sturgeon K.M., Williamson S.T., et al. (2011). Racial Differences in Oxidative Stress and Inflammation: in vitro and in vivo, Clinical and Translational Science, 4(1):32-7.

Brown M.D., Feairheller D.L., Thakkar S., Veerabhadrappa P., Park J.Y. (2011). Racial differences in tumor necrosis factor-α-induced endothelial microparticles and interleukin-6 production, Vascular Health and Risk Management, 7:541-550.

Feairheller D.L., Park J.Y., Rizzo V., Kim B. et al. (2011). Racial differences in the response to shear stress in human unbilical vein endothelial cells, Vascular Health and Risk Management, 7:1-7.

Zago A.S.,  Kokubun E., Fenty-Stewart N.M., Park J.Y., et al. (2010). Effect of physical activity and t-786C polymorphism in blood pressure and blood flow in the elderly, Arq Bras Cardiol, 95(4):510-6.

Zago A.S., Park J.Y., Fenty-Stewart N.M., Kokubun E., et al. (2010). Effects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older people, Eur J Appl Physiol, 110(4): 825-832.

Park J.Y., Wang P.Y., Matsumoto T., Sung, H.J., Ma W.Z., Choi J., Anderson S.A., Leary S.C., Balaban R.S., Kang, J.G., Hwang, P.M. (2009) p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content, Circulation Research, 105: 705-712.

Feairheller D.L., Brown M.D., Park J.Y., Brinkley T., et al. (2009). Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension. Med Sci Sports Exerc, 41(7): 1421-1428.

Brinkley T., Fenty-Stewart N., Park J.Y., Brown M.D., Hagberg J.M., et al. (2009). Plasma Nitrate/Nitrite Levels are Unchanged after Long-Term Aerobic Exercise Training in Older Adults, Nitric Oxide: Biology and Chemistry, 21(3-4): 234-238.

Fenty-Stewart N., Park J.Y., Basu S., Hagberg J.M., Ferrell R.E., Brown M.D., et al. (2009). Independent & combined influence of AGTR1 variants and aerobic exercise on oxidative stress in hypertensives, Blood Pressure, 18(4):204-212.
Attipoe S., Park J.Y., Fenty N., Phares D., Brown M.D., et al. (2008). Oxidative Stress Levels are Reduced in Postmenopausal Women with Exercise Training Regardless of Hormone Replacement Therapy Status, Journal of Women & Aging, 20:31-45
Park J.Y., Farrance I.K., Fenty N.M., Hagberg J.M., et al. (2007). NFKB1 promoter variation implicates shear-induced eNOS gene expression and endothelial function in pre and stage I hypertensives, American Journal of Physiology-Heart and Circulatory  Physiology, 293(4):H2320-H2327

Ma W., Sung H.J., Park J.Y., Matoba S., Hwang P.M. (2007). A pivotal role for p53: balancing aerobic respiration and glycolysis, J Bioenerg Biomembr, 39(3):243-6.

Jones J.M., Dowling T., Park J.J., Phares D.A., Park J.Y., Obisesan T., Brown M.D. (2007). Differential Aerobic Exercise-Induced Changes in Plasma Aldosterone between African American and White Prehypertensives & Hypertensives May Be Dependent on Baseline Plasma Aldosterone Levels, Experimental Physiology, 92(5):871-9.

Jones J.M., Park J.J., Dowling T., Phares D.A., Park J.Y., Brown M.D. (2006). Role of potassium excretion and percent body fat on ethnic differences in plasma aldosterone levels,  Ethnicity & Disease, 16(3 Suppl 4):S4-10-4.

Park J.Y., Ferrell R.E., Park J.J., Hagberg J.M., et al. (2005). NADPH Oxidase p22phox Gene Variants are Associated with Systemic Oxidative Stress Biomarker Responses to Exercise Training, Journal of Applied Physiology, 99: 1905-1911.
Weiss E.P., Park J.J.,McKenzie J.A., Park J.Y., Kulaputana O., Brown M.D., Phares D.A., Hagberg J.M. (2004). Plasma Nitrate/Nitrite Response to an Oral Glucose Load and the Effect of Endurance Training, Metabolism, 53(5):673-9.

Jin Y.S., Park J.Y., Kim H.Y., Lee H.J., et al. (2001). The effect of Aerobic and Qi-Gong on Lymphocyte, β-adrenergic receptor, antioxidative function, and heart rate variability in the elderly, Korean J of Sports Medicine, 19(2), 359-373.

Jin Y.S., Lee W.R., Park J.Y. (2001). The Effect of antioxidants supplementation on antioxidant enzyme activity of skeletal muscle immediately after maximal exercise in rats, Korean J of Sports Medicine, 19(1), 148-159.
Jin Y.S., Park K.K., Park J.Y., Kim M.J., et al. (2000). Effects of exercise-induced oxidative stress and antioxidant supplementation on NF-κB activation in peripheral mononuclear cells, Korean J of Sports Medicine, 18(2), 261-270.
Jin Y.S., Kim Y.K., Park E.K., Choi H.J., Park J.Y. (2000). The effects of long term stretching Exercise on Health Related Fitness of the Elderly Women, Korea Exercise Science Academy, 1-13.

Kim J.E., Kim Y.K., Lee H.J., Park E.K., Park J.Y., et al. (2000). The Correlation between isokinetic flexion-extension force of each joint and throwing speed in the softball pitcher,Korean J. Sports Medicine, 18(1): 33-40.

Jin Y.S., Kim M.J., Park J.Y., Kim Y.K., et al. (1999). The Effect Of Exercise Pattern And Antioxidant Supplement On Antioxidant Enzymes And Total Antioxidant Status, Korean J of Physical Education, 38(4):451-460.

Lee H.J., Kim J.E., Park J.Y., Kim Y.K., et al. (1999). Correlation analysis of muscular fatigue and torque during repeated isokinetic shoulder internal and external rotation, Korean J. of Sports Medicine, 17(2); 376-384.

Park J.Y., Kim M.J., Jung S.T., Jun T.W., et al. (1998). The Effect of Antioxidant Vitamins Supplementation on Exercise-Induced Acute Phase Response of T Lymphocyte and Natural Killer Cell, Korean J of Physical Education, 37(4): 380-389.

Jin Y.S., Kim M.J., Park J.Y., (1998). The Effects of Exercise Pattern on acute response of T lymphocyte and Natural Killer cell : to search a immunological threshold around AT level, Korean J. of Sports Medicine, 16(2):259-269.

Jin Y.S., Ryu H.S., Park J.Y. (1998). The Changes of Blood Total Antioxidant and MDA Concentration with Different Exercise Intensities, Korean J. of Sports Medicine, 16(2):252-258.

Jin Y.S., Park J.Y., Kim T.W., Kim M.H., et al. (1998). The Validity of Anaerobic Capacity and Fatigue Index of Wingate Test, Korean J. of Sports Medicine 16(1): 97-106.

Jin Y.S., Kim Y.K., Kim J.H., Park J.Y. (1998). The Effects of Exercise and Diet on patterns of Body Fat Distribution, Korean J. of Sports Medicine 16(1): 67-76.

Kim Y.K., Jin Y.S., Kim M.H., Park J.Y., et al. (1997). The Effect of Exercise Training and Low Calory Diet on Weight Loss and Body Fat Distribution in Obese Women, Korean J of Physical Education, 36(3)114-122.

Jin Y.S., Kim Y.K., Kim J.H., Park J.Y., et al. (1997). The Correlation between Throwing Speed and Shoulder Internal/External Rotators & Trunk Flexion/Extension in the Professional Baseball Pitchers, Korean J. of Sports Medicine.15(1)58-66.

Jin Y.S., Kim M.H., Kim J.H., Park J.Y., et al. (1995). The comparisons of peak isokinetic functions of Knee Joint between Normal and PFPS patient, Korean J. of Sports Medicine.13(2)114-123.

Recent Presentations

Combined effect of flow-mediated shear stress and resveratrol on Sirt1 / PGC-1α pathway in vascular endothelial cells, Experimental Biology, San Diego, CA (2012).

Functional study of tumor suppressor p53 gene variation: effect on cardiovascular adaptation to exercise training, Experimental Biology, San Diego, CA (2012).

Exercise-like levels of shear stress modulate the vasomotor control mediators nitric oxide and endothelin-1, American Heart Association High Blood Pressure Research Meeting, Orlando, FL (2011).

eNOS Phosphorylation Under Flow-Mediated Shear Stress: Effects of Flow Pattern and Ambient Oxygen
Concentration, 58th American College of Sports Medicine, Denver, CO (2011).

Effects of Laminar Shear Stress on Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells, 58th American College of Sports Medicine, Denver, CO (2011).

In Vitro Shear Stress Responses of Endothelin-1 in African American and Caucasian HUVECs, 58th American College of Sports Medicine, Denver, CO (2011).

Translational Approach to Understanding Endothelial Adaptations to Exercise, 58th American College of Sports Medicine, Denver, CO (2011).

Endothelial Nitric Oxide Synthase Activation: Laminar Shear Stress vs. Low Oxidant Conditions, 58th American College of Sports Medicine, Denver, CO (2011).

Effects of Laminar Shear Stress on Race-dependent Oxidative Stress Responses in Human Umbilical Vein Endothelial Cells, Experimental Biology, Washington DC (2011).

Laminar Shear Stress Pre-Conditioning Restores VEGFR2 Activation Following an Oxidant Challenge in Endothelial Cells, Experimental Biology, Washington DC (2011).

Effects of TNF-α stimulation on NOS expression in racially-derived HUVECs, Temple Fellow Retreat, Philadelphia, PA 2010

Racial Differences in Tumor Necrosis Factor-alpha-Induced Endothelial Microparticle and Interleukin-6 Production, American Heart Association-High Blood Pressure Research Conference, DC (2010).

Mitochondrial fission protein Drp1 plays a crucial role for myotube differentiation by regulating mitochondria-mediated apoptosis, American Physiological Society-ACSM Integrated Physiology of Exercise, Miami, FL (2010).

Effects of Oxygen Tension in Shear Stress-Induced eNOS Activation in Human Endothelial Cells, American Physiological Society-ACSM Integrated Physiology of Exercise, Miami, FL (2010).

Greater Cardiovascular Adaptation to Aerobic Exercise Training in Arginine-Allele Carriers of p53 codon 72 Arginine/Proline Polymorphism in Individuals having Pre-Hypertension, CPH Research Festival, Temple University, PA (2010).

Differentiating racial differences in oxidative stress levels: in vitro and in vivo, Experimental Biology, Anaheim, CA (2010).

Grants & Contracts

Flow Shear Stress-Induced Mitochondrial Biogenesis in Endothelial Cells (P.I.), National Scientist Development Grant, American Heart Association (2012-2016)

Effects of Laminar Shear Stress on Mitochondrial DNA Integrity in Endothelial Cells (P.I., Primary Sponsor), Predoctoral Fellowship Grant, American Heart Association, (2012-2014)

TempleUniversity Internal Grant, Research Support (2012)


1. Flow shear stress-mediated mitochondrial adaptation in vascular endothelium
2. Physiological role of mitochondrial fission event in exercise-mediated muscle adaptation
3. Effects of caloric restriction on bi-directional crosstalk between muscle and bone


Our research projects involve techniques in Physiology, Cell Biology, Molecular Genetics including mechanical shear stress, primary cell culture, genetically engineered mouse models, genotyping, mitochondrial functional assays, mtDNA mutation assays, Gain- and lose-of function studies, High throughput gene expression study, Treadmill and voluntary wheel running exercise, and biochemical assays with human blood and circulating cells.

Additional Info